Genetic alterations that activate protein kinase A (PKA) are found in many tumor types. Yet. their downstream oncogenic signaling mechanisms are poorly understood. We used global phosphoproteomics and kinase activity profiling to map conserved signaling outputs driven by a range of genetic changes that activate PKA in human cancer. https://hollandscountryclothinges.shop/product-category/gaiters/
Oncogenic PKA signaling increases c-MYC protein expression through multiple targetable mechanisms
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